Submitted by: Ashley Ulm
Program: Biomedical Visualization
Division: Life Sciences
This video was created to describe the exciting new advances that are being explored in liver transplant options. The method described involves taking a liver that is healthy but not suitable for transplant as is, and removing the cells. Meanwhile, cells harvested from the patient are reprogrammed into stem cells, then directed in culture to become healthy liver cells. These new liver cells are seeded into the original liver scaffold. This process creates a "customized" and healthy liver that could potentially reduce the risk of organ rejection. The animation takes the viewer through each of these steps in order to make the process more understandable and approachable.
Mazza, G., Rombouts, K., Hall, A. R., Urbani, L., Luong, T. V., Al-Akkad, W., ... & Fuller, B. (2015). Decellularized human liver as a natural 3D-scaffold for liver bioengineering and transplantation. Scientific reports, 5, 13079.